The responses peaked mainly at week 1 and then decayed rapidly to very low levels within 6 weeks. IgG1 and IgG3 responses to five recombinant Plasmodium falciparum merozoite antigens (MSP-1 19, MSP-2 type A and B, AMA-1 ectodomain and EBA-175 region II) among Kenyan children were monitored using ELISA for 12 weeks after an acute episode of malaria and their half-lives estimated using an exponential decay model. However, precise data on the kinetics of these responses is lacking.
Data suggest that antibody responses to malaria parasites merozoite antigens are generally short-lived and this has implications for serological studies and malaria vaccine designs.